IGF-1 LR3（10 VIALS / BOX）
Synthetic Peptide for Growth Factor Research
Technical Overview
IGF-1 LR3 1mg is a synthetic peptide compound developed for laboratory research involving insulin-like growth factor signaling and somatomedin pathway analysis, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying IGF-1 receptor activation profiles, PI3K/Akt and MAPK pathway dynamics, and related biochemical mechanisms.
IGF-1 LR3 is a recombinant 83-residue IGF-1 analog with arginine substituted for glutamic acid at position 3 and an additional 13-residue N-terminal extension. These modifications dramatically reduce binding to IGF binding proteins (IGFBP-1 through IGFBP-6), increasing the proportion of bioavailable peptide for receptor interaction in cell-culture systems.
Researchers utilize this analog to study cell-cycle progression, protein synthesis, and survival signaling in myoblast, hepatocyte, and stem-cell models. Its reduced IGFBP affinity makes it a preferred tool for distinguishing receptor-mediated effects from binding-protein-mediated sequestration.
This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.
Specifications
Compound Name: IGF-1 LR3
Strength: 1mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.
Notice
Provided as a reference material for scientific investigation only.
Product Specifications
| CAS Number | 946870-92-4 |
|---|---|
| Molecular Formula | C400H625N111O115S9 |
| Molecular Weight (g/mol) | 9117.60 |
| Amino Acid Count | 83 |
| Amino Acid Sequence | 83-residue recombinant IGF-1 analog with Arg substituted for Glu at position 3 and a 13-residue N-terminal extension; modifications reduce IGFBP affinity and extend circulating half-life relative to native IGF-1 (full sequence per COA). |
| Purity | 99% by HPLC COA available |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations. |
| Storage Conditions | Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; store reconstituted material refrigerated and use per laboratory protocol. |
For Research Use Only. Not for use in diagnostic, therapeutic, or human or animal in-vivo procedures. This product is sold exclusively for in-vitro laboratory research use. It is not a drug, dietary supplement, food, or cosmetic and has not been approved by the U.S. Food and Drug Administration for any use. Not for human or animal consumption.
